Convergent Synthesis of Digitoxin: Stereoselective Synthesis and Glycosylation of the Digoxin Trisaccharide Glycal This research was supported by the U.S. National Institutes of Health (CA-59703). F.E.M. also thanks Novartis Pharmaceuticals for unrestricted additional funding (Grant Program for the Support of Academic Research in Synthetic Organic Chemistry).

2001 ◽  
Vol 40 (19) ◽  
pp. 3653 ◽  
Author(s):  
Frank E. McDonald ◽  
K. Subba Reddy
Keyword(s):  
Organic Chemistry ◽  
Stereoselective Synthesis ◽  
Academic Research ◽  
National Institutes Of Health ◽  
Convergent Synthesis ◽  
Synthetic Organic Chemistry ◽  
Grant Program ◽  
Additional Funding ◽  
The U.S

scholarly journals Synthesis of spirocyclic scaffolds using hypervalent iodine reagents

2018 ◽  
Vol 14 ◽  
pp. 1778-1805 ◽  
Author(s):  
Fateh V Singh ◽  
Priyanka B Kole ◽  
Saeesh R Mangaonkar ◽  
Samata E Shetgaonkar
Keyword(s):  
Organic Chemistry ◽  
Heavy Metals ◽  
Natural Product ◽  
Organic Synthesis ◽  
Stereoselective Synthesis ◽  
Natural Product Synthesis ◽  
Hypervalent Iodine ◽  
Toxic Heavy Metals ◽  
Synthetic Organic Chemistry ◽  
The Past

Hypervalent iodine reagents have been developed as highly valuable reagents in synthetic organic chemistry during the past few decades. These reagents have been identified as key replacements of various toxic heavy metals in organic synthesis. Various synthetically and biologically important scaffolds have been developed using hypervalent iodine reagents either in stoichiometric or catalytic amounts. In addition, hypervalent iodine reagents have been employed for the synthesis of spirocyclic scaffolds via dearomatization processes. In this review, various approaches for the synthesis of spirocyclic scaffolds using hypervalent iodine reagents are covered including their stereoselective synthesis. Additionally, the applications of these reagents in natural product synthesis are also covered.

Recent Developments in the Asymmetric Detrifluoroacetylative Reactions of in situ Generated Mono-Fluorinated Enolates

2020 ◽  
Vol 24 (18) ◽  
pp. 2181-2191
Author(s):  
Li Wang ◽  
Ziyi Li ◽  
Jiang Liu ◽  
Jianlin Han ◽  
Hiroki Moriwaki ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Bond Cleavage ◽  
Synthetic Methodology ◽  
Research Topics ◽  
Synthetic Organic Chemistry ◽  
Nucleophilic Reactions ◽  
F Center ◽  
Recent Developments

The development of an efficient and mild synthetic methodology for the construction of bioactive fluorine-containing molecules represents one of the hot research topics in general synthetic organic chemistry. In this review, some recent progresses achieved in the development of detrifluoroacetylatively generated mono-fluorinated enolates via CC bond cleavage and their asymmetric nucleophilic reactions for assembly of chiral quaternary C-F center containing compounds.

HIV

2018 ◽  
Author(s):  
Joshua M. Sharfstein
Keyword(s):  
Public Health ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Research Process ◽  
National Institutes Of Health ◽  
Health Agencies ◽  
Act Up ◽  
The U.S

The emergence of AIDS in the early 1980s caused a profound crisis for federal health agencies, particularly the National Institutes of Health (NIH) and the U.S. Food and Drug Administration (FDA). Activists in ACT UP, charging that these agencies were failing patients with AIDS, initiated a series of escalating protests. NIH officials, led by Dr. Anthony Fauci, began to talk with the advocates and make major changes in the research process. However, over at the FDA, a protest involving the arrest of hundreds of AIDS activists undermined the agency’s public health image. Eventually, under a new commissioner, the FDA earned back the trust of activists.

An approach to computer-assisted drill in synthetic organic chemistry

1973 ◽  
Vol 50 (9) ◽  
pp. 645
Author(s):  
H. A. Clark ◽  
J. C. Marshall ◽  
T. L. Isenhour
Keyword(s):  
Organic Chemistry ◽  
Computer Assisted ◽  
Synthetic Organic Chemistry

Recent advances and perspectives in manganese-catalyzed C–H activation

2021 ◽  
Author(s):  
Thaipparambil Aneeja ◽  
Mohan Neetha ◽  
C. M. A. Afsina ◽  
Gopinathan Anilkumar
Keyword(s):  
Organic Chemistry ◽  
Synthetic Organic Chemistry ◽  
Recent Advances

Manganese-catalyzed C–H activation has become an emerging area in organic chemistry. These efficient and eco-friendly manganese catalysed reactions provides new opportunities in the field of synthetic organic chemistry.

A review of the recent progress on heterogeneous catalysts for Knoevenagel condensation

2021 ◽  
Vol 50 (13) ◽  
pp. 4445-4469
Author(s):  
Jimmy Nelson Appaturi ◽  
Rajni Ratti ◽  
Bao Lee Phoon ◽  
Samaila Muazu Batagarawa ◽  
Israf Ud Din ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Heterogeneous Catalysts ◽  
Recent Progress ◽  
Knoevenagel Condensation ◽  
Sustainable Production ◽  
Organic Reactions ◽  
Synthetic Organic Chemistry

One of the most crucial attributes of synthetic organic chemistry is to design organic reactions under the facets of green chemistry for the sustainable production of chemicals.

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